Studien und Quellen

Die Quellen hinter der DNA

Hier findest du die Quellen, die zur Entwicklung der DNA Analyse beigetragen haben

VERLORENES GEWICHT WIEDER ZUNEHMEN

Goyenechea et al. (2009). The – 11391 G/A polymorphism of the adiponectin gene promoter is associated with metabolic syndrome traits and the
outcome of an energy-restricted diet in obese subjects. Horm Metab Res 41(1): 55-61

DAS RISIKO FÜR DIE ENTWICKLUNG VON ÜBERGEWICHT

Benzinou et al. (2008). Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet 40(8): 943-945
Cheung et al. (2010). Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese
population. J Clin Endocrinol Metab 95(3): 1395-1403
Heard-Costa et al. (2009). NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
PLoS Genet 5(6): e1000539
Herbert et al. (2006). A common genetic variant is associated with adult and childhood obesity. Science 312(5771): 279-283
Sookoian et al. (2005). Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic
syndrome. Obes Res 13(12): 2122-2131
Thorleifsson et al. (2009). Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat
Genet 41(1): 18-24
Wang et al. (2011). A genome-wide association study on obesity and obesity-related traits. PLoS One 6(4)
Wheeler et al. (2013). Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset
obesity. Net Genet 45(5): 513-517
Willer et al. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41(1): 25-34
Xi et al. (2013). Study of 11 BMI-Associated Loci Identified in GWAS for Associations with Central Obesity in the Chinese Children. PLoS ONE 8(2)
Zhang et al. (2012). FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS
LOST Trual. Diabetes. 61(11):3005-30011

DIE REAKTION AUF GESÄTTIGTE FETTE

Corella et al. (2009). APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. Arch Intern
Med 169(20): 1897-1906
Smith et al. (2013). Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations. J Nutr.
143(12):1865-1871

DIE REAKTION AUF EINFACH UNGESÄTTIGTE FETTE

Warodomwichit et al. (2009). ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study. Obesity 17(3): 510-517
Warodomwichit et al. (2009). The monounsaturated fatty acid intake modulates the effect of ADIPOQ polymorphisms on obesity. Obesity (Silver
Spring) 17(3): 510-517

DIE REAKTION AUF MEHRFACH UNGESÄTTIGTE FETTE

Contreras et al. (2013). PPAR-alpha as a Key Nutritional and Environmental Sensor for Metabolic Adaptation. Adv Nutr. 4(4): 439–452
Rudkowska et al. (2014). Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation.
J Lipid Res.55(7): 1245–1253
Tai et al. (2005). Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III
concentrations in the Framingham Heart Study. J Nutr 135(3): 397-403

DIE REAKTION AUF KOHLENHYDRATE

Junyent et al. (2009). Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol
concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. Am J Clin Nutr, 90(3): 686-694
Sonestedt et al. (2009). Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J
Clin Nutr 90(5): 1418-1425

VITAMINE

de Bree et al. (2003). Effect of the methylenetetrahydrofolate reductase 677C–>T mutation on the relations among folate intake and plasma folate
and homocysteine concentrations in a general population sample. Am J Clin Nutr 77(3): 687-693
Ferrucci et al. (2009). Common variation in the beta-carotene 15,15’ monooxygenase 1 gene affects circulating levels of carotenoids: a genomewide association study. Am J Hum Genet 84(2):123-33
Hazra et al. (2009). Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet 18(23): 4677-4687
Major et al. (2012). Genome-wide association study identifies three common variants associated with serologic response to vitamin E
supplementation in men. J Nutr 142(5): 866-871
Major et al. (2011). Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum Mol Genet 20(19):
3876-3883
Tanaka et al. (2009) . Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum
Genet 84(4): 477-482
Thuesen et al. (2010). Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr 103(8): 1195-1204
Wang et al. (2010). Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376(9736): 180-188
Yazdanpanah et al. (2008) . Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the
MTHFR 677 T allele. J Bone Miner Res 23(1):86-94

MINERALE

Barlassina et al. (2007). Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension. Hum Mol
Genet 16(13): 1630-1638
Benyamin et al. (2009). Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet
84(1): 60-65
Newhouse et al. (2009). Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. PLoS
One 4(4): e5003
Norat et al. (2008). Blood pressure and interactions between the angiotensin polymorphism AGT M235T and sodium intake: a cross-sectional
population study. Am J Clin Nutr 88(2): 392-397
Tanaka et al. (2010). A genome-wide association analysis of serum iron concentrations. Blood 115(1): 94-96

KNOCHENDICHTE

Estrada et al. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat
Genet 44(5): 491-501
Grant et al. (1996). Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat
Genet 14(2): 203-205
Guillem et al. (2012). Refining perception-based farmer typologies with the analysis of past census data. J Environ Manage 110: 226-235
Keen et al. (1999). Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk,
and increased collagen turnover. Arthritis Rheum 42(2): 285-290
Liu et al. (2010). Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. J Clin Endocrinol Metab 95(9): E112-120
Mann et al. (2001). A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J Clin
Invest 107(7): 899-907
Richards et al. (2008). Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371(9623):
1505-1512
Richards et al. (2012). Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet 13(8):576-588
Rivadeneira et al. (2009). Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat
Genet 41(11): 1199-1206
Zhang et al. (2014). Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet 23(7):
1923-1933 (PMID: 24249740)
Zhang et al. (2014). Relation of JAGGED 1 and collagen type 1 alpha 1 polymorphisms with bone mineral density in Chinese postmenopausal
women. Int J Clin Exp Pathol 7(10): 7142-7147

DER KONSUM VON SÜSSIGKEITEN

Mäestu et al. (2007). Human adrenergic alpha 2A receptor C-1291G polymorphism leads to higher consumption of sweet food products. Mol
Psychiatry 12(6): 520-521

UNERSÄTTLICHKEIT UND HUNGER

Bouchard et al. (2004). Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity. Am J Clin Nutr 80(6):
1478-1486
Frayling et al. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
Science 316(5826): 889-894
Wardle et al. (2008). Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab. 93(9):3640-3643

DIE WAHRNEHMUNG DES SÜSSEN GESCHMACKS

Eny et al. (2008). Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations. Physiol
Genomics 33(3): 355-360

DIE WAHRNEHMUNG DES BITTEREN GESCHMACKS

Desai et al. (2011). Validation of edible taste strips for identifying PROP taste recognition thresholds. Laryngoscope 12(6): 1177-1183
Ledda et al. (2014). GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics. Hum Mol
Genet 23(1): 259-267
Timpson et al. (2007). Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon
Longitudinal Study of Parents and Children. BMC Genet 8: 51

DER ALKOHOLSTOFFWECHSEL

Chen et al. (2009). Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and
pharmacodynamic consequences. Chem Biol Interact 178(1-3): 2-7
Martínez et al. (2010). Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes. Hepatology
51(2): 491-500
Matsuo et al. (2006). Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2
Glu487Lys polymorphism: analysis of 2,299 Japanese subjects. Cancer Epidemiol Biomarkers Prev 15(5): 1009-1013
Yokoyama et al. (2005). Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular
volume in Japanese workers. Alcohol Clin Exp Res 29(7): 1165-1171

DER KOFFEINSTOFFWECHSEL

Cornelis et al. (2006). Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA 295(10): 1135-1141
Palatini et al. (2009). CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J Hypertens 27(8): 1594-1601
Sachse et al. (1999). Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br
J Clin Pharmacol. 47(4):445-449

DER LAKTOSESTOFFWECHSEL

Bersaglieri et al. (2004). Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 74(6): 1111-1120
Enattah et al. (2002). Identification of a variant associated with adult-type hypolactasia. Nat Genet 30(2): 233-237
Heyer et al. (2011). Lactase persistence in central Asia: phenotype, genotype, and evolution. Hum Biol 83(3): 379-392
Kerber et al. (2007). Hydrogen breath testing versus LCT genotyping for the diagnosis of lactose intolerance: a matter of age? Clin Chim Acta
383(1-2): 91-96
Krawczyk et al. (2008). Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre. J Gastrointestin Liver Dis
17(2): 135-139
Nagy et al. (2009). Prevalence of adult-type hypolactasia as diagnosed with genetic and lactose hydrogen breath tests in Hungarians. Eur J Clin
Nutr 63(7): 909-912

GLUTEN INTOLERANZ

Hunt et al. (2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet. 40(4): 395-402.
van Heel et al. (2007). A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet.
39(7): 827-829.
Monsuur et al. (2008). Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.
PLoS One. 3(5):e2270
Zhernakova et al. (2011). Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA
shared loci. PLoS Genet. 7(2 ): e1002004

OXIDATIVER STRESS

Hu in Diamond (2003). Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Cancer Res 63(12): 3347-3351
Moran et al. (1999). A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone
oxidoreductase 1 (NQO1) to benzene toxicity. Proc Natl Acad Sci U S A 96(14): 8150-8155
Nadif et al. (2005). Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. Free Radic Res
39(12): 1345-1350
Perianayagam et al. (2007). NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse
outcomes in acute renal failure. J Am Soc Nephrol 18(1): 255-263
Ratnasinghe et al. (2000). Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. Cancer Res 60(22): 6381-6383
Ross (2005). Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity. Chem Biol Interact 153-154: 137-146
Saldivar et al. (2005). An association between a NQO1 genetic polymorphism and risk of lung cancer. Mutat Res. 582(1-2): 71-78
Siegel et al. (1999). Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1. Pharmacogenetics
9(1): 113-121
Smith (1999). Benzene, NQO1, and genetic susceptibility to cancer. Proc Natl Acad Sci U S A 96(14): 7624-7626
Zhao et al. (2012). Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study. BMC Cancer 12: 617

SELEN

Méplan et al. (2007). Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium
supplementation in a gender-specific manner (the SELGEN study). FASEB J 21(12): 3063-3074
Xia et al. (2010). Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement:
a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Am J Clin Nutr 92(3):
525-531
Xiong et al. (2010). Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease. Osteoarthritis
Cartilage 18(6): 817-824

VITAMIN E

Ferrucci et al. (2009). Common variation in the beta-carotene 15,15’ monooxygenase 1 gene affects circulating levels of carotenoids: a genomewide association study. Am J Hum Genet 84(2):123-33
Major et.al. (2011). Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum Mol Genet
20(19): 3876-3883
Major et al. (2012). Genome-wide association study identifies three common variants associated with serologic response to vitamin E
supplementation in men. J Nutr 142(5): 866-871

VITAMIN C

Timpson et al. (2010). Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence
from 5 independent studies with >15,000 participants. Am J Clin Nutr. 92(2):375-382

MUSKELSTRUKTUR

Ahmetov et al. (2006). PPARalpha gene variation and physical performance in Russian athletes. Eur J Appl Physiol 97(1): 103-108
Eynon et al. (2010). Do PPARGC1A and PPARalpha polymorphisms influence sprint or endurance phenotypes? Scand J Med Sci Sports. 20(1):e145-50
Eynon et al. (2012). The ACTN3 R577X polymorphism across three groups of elite male European athletes. PLoS One 7(8): e43132
Kikuchi et al. (2015). The ACTN3 R577X genotype is associated with muscle function in a Japanese population. Appl Physiol Nutr Metab 40(4):
316-322
Kikuchi et al. (2016). ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes. Eur J Sport Sci 16(6): 694-701
Papadimitriou et al. (2016). ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study. BMC Genomics.
17(1): 285
Yang et al. (2003). ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet 73(3): 627-631

KRAFTTRAINING

Orkunoglu-Suer et al. (2008). INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance
training in men. BMC Med Genet 9:117
VO2MAX (IHR AEROBES POTENTIAL)
Ahmetov et al. (2009). The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. Hum
Genet. 126(6):751-761
Defoor et al. (2006). The CAREGENE study: ACE gene I/D polymorphism and effect of physical training on aerobic power in coronary artery
disease. Heart. 92(4):527-528
Hagberg et al. (1998). VO2 max is associated with ACE genotype in postmenopausal women. J Appl Physiol. 85(5):1842-1846
Hagberg et al. (2002). ACE insertion/deletion polymorphism and submaximal exercise hemodynamics in postmenopausal women. J Appl Physiol.
92(3):1083-1088
Hennis et al. (2015). Genetic factors associated with exercise performance in atmospheric hypoxia. Sports Med. 2015 May;45(5):745-61. doi:
10.1007/s40279-015-0309-8.
Lucia et al. (2005). PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men. J Appl Physiol (1985). 99(1):344-348
Maciejewska et al. (2012). The PPARGC1A gene Gly482Ser in Polish and Russian athletes. J Sports Sci. 30(1):101-113
Masschelein et al. (2015). A genetic predisposition score associates with reduced aerobic capacity in response to acute normobaric hypoxia in
lowlanders. High Alt Med Biol. 16(1):34-42

Patel et al. (2003). Angiotensin-converting enzyme genotype and the ventilatory response to exertional hypoxia. Eur Respir J.22(5):755-60.
Sarpeshkar et al. (2010). Adrenergic-beta(2) receptor polymorphism and athletic performance. J Hum Genet. 55(8):479-485
Stefan et al. (2007). Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and
insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab. 92(5):1827-1833
Tsianos et al. (2010). Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon
runners. J Appl Physiol. 108(3):567-574

VERLETZUNGSRISIKO DES WEICHEN GEWEBES

Bastaki et al. (2006). Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans.
Pharmacogenet Genomics. 16(4):279-286
Caple et al. (2010). Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary
supplementation and genotype. Br J Nutr. 103(11):1585-1593
D’souza et al. (2008). Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association
as a risk factor in SLE. BMC Med Genet. 9:62.
Forsberg et al. (2001). A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences
transcription factor binding, reporter gene transcription and is correlated to blood catalase levels. Free Radic Biol Med. 30(5):500-505
Mohammedi et al. (2014). Manganese superoxide dismutase (SOD2) polymorphisms, plasma advanced oxidation protein products (AOPP)
concentration and risk of kidney complications in subjects with type 1 diabetes. PLoS One. 9(5):e96916.
Nadif et al. (2005). Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. Free Radic Res.
39(12):1345-1350
Najafi et al. (2012). Phenotype and genotype relationship of glutathione peroxidase1 (GPx1) and rs 1800668 variant: the homozygote effect on
kinetic parameters. Gene. 505(1):19-22
Perianayagam et al. (2007). NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse
outcomes in acute renal failure. J Am Soc Nephrol. 18(1):255-263
Ross et al. (2000). NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms.
Chem Biol Interact. 129(1-2):77-97

HERZKAPAZITÄT

Hagberg et al. (2002). ACE insertion/deletion polymorphism and submaximal exercise hemodynamics in postmenopausal women. J Appl Physiol
(1985). 2002 Mar;92(3):1083-1088
Rankinen et al. (2010). CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family
Study. Circ Cardiovasc Genet. 3(3):294-299

GEN FÜR MUSKELVOLUMEN

Nielsen et al. (2007). Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition. J Physiol. 584(Pt
1):305-12
Pistilli et al. (2008). Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome.
Cytokine. 43(1):45-53
Riechman et al. (2004). Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training
responses. J Appl Physiol (1985). 97(6):2214-2219

KRIEGERGEN

Zubieta et al. (2003). COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science. 299(5610):1240-1243
Mitaki et al. (2013). Impact of five SNPs in dopamine-related genes on executive function. Acta Neurol Scand. 127(1):70-76
Stein et al. (2006). Warriors versus worriers: the role of COMT gene variants. CNS Spectr. 11(10):745-748

FETTFREIE KÖRPERMASSE

Liu et al. (2009). Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. Am J Hum Genet.
84(3):418-423

GEN FÜR MUSKELERMÜDUNG

Cupeiro et al. (2010). MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. J Sci Med Sport. 13(5): 526-530
Fetodovskaya et al. (2014). A common polymorphism of the MCT1 gene and athletic performance. Int J Sports Physiol Perform. 9(1): 173-180
Sawczuk et al. (2015). MCT1 A1470T: a novel polymorphism for sprint performance? J Sci Med Sport. 18(1): 114-118

NIKOTINSUCHT

Thorgeirsson et al. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452(7187): 638-642
Liu et al. (2010) . Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 42(5): 436-440
Thorgeirsson et al. (2010) . Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 42(5): 448-453

ALKOHOLSUCHT

hen et al. (2012). Smoking and genetic risk variation across populations of European, Asian, and African American ancestry–a meta-analysis of
chromosome 15q25. Genet Epidemol 36(4): 340-351
Haller et al. (2014). Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. Hum Mol Genet
23(3): 810-819
Liu et al. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 42(5): 436-440
Thorgeirsson et al. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452(7187): 638-642
Thorgeirsson et al. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 42(5): 448-453

BIOLOGISCHES ALTERN

Codd et al. (2010). Common variants near TERC are associated with mean telomere length. Nat Genet 42(3): 197-199
Mangino et al. (2012). Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol
Genet 21(24): 5385-5394
Soerensen et al. (2012). Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal
analysis. Aging Cell 11(2): 223-227
Shen et al. (2011). Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population. Eur J Hum Genet
19(6): 721-723

ENTZÜNDUNGSEMPFINDLICHKEIT

Jianf et al. (2010). Interleukin-6 receptor gene polymorphism modulates interleukin-6 levels and the metabolic syndrome: GBCS-CVD. Obesity
(Silver Spring) 18(10): 1969-1974
Kardys et al. (2006). C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study. Eur Heart J 27(11): 1331-1337
Mori and Beilin. (2004). Omega-3 Fatty Acids and Inflammation. Curr Atheroscler Rep. 6(6): 461-467
Pai et al. (2008). C-Reactive Protein (CRP) Gene Polymorphisms, CRP Levels, and Risk of Incident Coronary Heart Disease in Two Nested CaseControl Studies. PLoS One 3(1): e1395
Scheller et al. (2011). The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 1813(5): 878-888.
Simopoulos. (2002). Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases. J Am Coll Nutr 21(6): 495-505
Vargas et al. (2013). Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals
with metabolic syndrome. Genet Mol Res 2(3): 3983-3991.
Walston et al. (2010). Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Exp Gerontol
44(5): 350–355.
Wypasek et al. (2015). Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with
Aortic Stenosis. Int J Mol Sci 16(10): 23745–2375

SCHLAFZYKLUS

Benedetti et al. (2007). Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar
depression. Am J Med Genet B Neuropsychiatr Genet 144B(5): 631-635
Katzenberg et al. (1998). A CLOCK polymorphism associated with human diurnal preference. Sleep. 21(6): 569-576
Mishima et al. (2005). The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese
population sample. Am J Med Genet B Neuropsychiatr Genet 133B(1): 101-104
HDL-CHOLESTERIN, LDL-CHOLESTERIN UND TRIGLYZERIDE
Chasman et al. (2009). Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
PLoS Genet 5(11): e1000730
Do et al. (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 45(11): 1345-1352
Kathiresan et al. (2008). Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides
in humans. Nat Genet 40(2): 189-197
Lange et al. (2014). Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum
Genet 94(2):233-245
Teslovich et al. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466(7307): 707-713
Tukiainen et al. (2012). Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci. Hum Mol Genet 21(6):
1444-1455

BLUTZUCKER

Dupuis et al. (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42(2): 105-116
Hu et al. (2009). PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in
a Chinese population. PLoS One 4(10): e7643
Pang et al. (2013). Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes. Nutr Metab Cardiovasc Dis. 23(6):550-6.
Wu et al. (2008). Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and
impaired fasting glucose in a Chinese Han population. Diabetes 57(10): 2834-2842
Xiang et al. (2008). Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab 93(10): 4107-4112

OMEGA-3-STOFFWECHSEL

Ferguson J et al. (2010). NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3
polyunsaturated fatty acids. Atherosclerosis. 211:539-544.
Harsløf et al. (2013). FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. Am J Clin Nutr
97(6): 1403-10
Lemaitre et al. (2011). Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from
the CHARGE Consortium. PLoS Genet 7(7): e1002193

OMEGA-3 UND TRIGLYCERIDE

AlSaleh et al. (2014). Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after
controlled intake of n-3 polyunsaturated fatty acids. Genes Nutr 9(4): 412
Bradberry and Hilleman (2013). Overview of Omega-3 Fatty Acid Therapies. P T 38(11): 681–691
Dumont et al. (2011). FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations
in European adolescents. J Nutr 141(7): 1247-1253

Lu et al. (2010). Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol
concentrations in the Doetinchem Cohort Study. Am J Clin Nutr 92(1): 258-265
Harris and Bulchandani (2006). Why do omega-3 fatty acids lower serum triglycerides? Curr Opin Lipidol 17(4): 387-393

INSULINEMPFINDLICHKEIT

Heni et al. (2010). Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion. BMC Med Genet. 11:86
Goyenechea et al. (2009). The – 11391 G/A polymorphism of the adiponectin gene promoter is associated with metabolic syndrome traits and the
outcome of an energy-restricted diet in obese subjects. Horm Metab Res. 41(1):55-61
Palmer et al. (2008). Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol
Metab. 93(1): 304-309

ADIPONECTIN

Nigro et al. (2014). New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int 2014: 658913.
Hivert et al. (2008). Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetesrelated quantitative traits: the Framingham Offspring Study. Diabetes 57(12): 3353-3359
Yoon et al. (2006). Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase,
p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 55(9): 2562-2570

C-REAKTIVES PROTEIN (CRP)

Arguinano et al. (2017). IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels. Genes
Immun. 18(3):163-169
Eiriksdottir et al. (2009). The interaction of adiposity with the CRP genes affects CRP levels: age, gene/environmentsusceptibility-Reykjavik
study. Int J Obes. 33(2):267-272
Naitza et al. 2012. A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin
Its Complex Regulation. PloS Genet. 8(1):e1002480
Reiner et al. (2008). Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1alpha are Associated with C-Reactive Protein. Am
J Hum Genet. 82(5): 1193-1201